Abstract: In the study, the development of communication in desert regions in ancient China is introduced systematically. The sellection of communication line, by using favorable topography of natural geography, in desert regions was concerned in ancient China, for example, the communication line commonly sellected to develop at alluvial plains or at wide valley plains and along the sides of basins, oasis and riversides. These experiences possess an important significance to be reference for the development of communication in desert regions in the present time.