There is 61.5 kilometers wind-sand subgrade in the Data-Hejiata Railway, accounting for 48.7% of the entire line length. The blown sand hazard has seriously threatened the normal operation of the line and the external transport of mineral resources. Based on the investigation of the local climate, vegetation types, distribution of dunes and other factors, a comprehensive treatment scheme combining engineering and plant protections was determined. The plants including Salix mongolica, Caraganakorshinskii, Hedysarumlaeve Maxim and Populus diversifolia were chosen, many protection measures were carried out, for example, high vertical barrier, HDPE nylon net barrier, live sand barrier of Salix mongolica squares. The different levels of sand prevention measures were carried out at semi-fixed sand dune and mobile dune zone according to different damage degree of the wind-sand subgrade, a sand prevention system of rigorous and integrated was constructed. Practice has proved that a complete green protection system has been formed by building the live sand barrier and the plant protection forest belt, this system prevents and stabilizes the blown sand, greatly reduces the possibility of blown sand damaging, guarantees the safe operation of the railway, and accumulates valuable experience for blown sand control of the desert railway in similar areas.