In order to implement the spirit of General Secretary Xi Jinping's speech on strengthening comprehensive prevention and control of desertification， further promote the construction of the "Three North" and other key ecological projects and win the battle against desertification in the core area of the Hexi Corridor-Taklimakan Desert edge （defined as “Battle Zone”）， the study of the management regionalization and the zoning management tasks in the core area of the Battle Zone were presented in this paper. According to the characteristics of sandy land and sand activities in the region， using "sand source is no longer causing damage and dust source is effectively controlled " as the goal， this paper systematically sorted out and analyzed the sources of wind， sand and dust， the law and path of sand transmission and its influence range， the natural geographical characteristics and the spatial distribution of the source of dust， wind and sand， protection gap between oasis， encroachment of sand outside oasis. Based on the above analyses， the management regionalization and the key zoning management tasks in the region were presented， so as to provide scientific support for the battle against desertification in the core area of the Hexi Corridor-Taklimakan Desert edge.