Lake changes sensitively recorded the messages of climate change. The Horqin typical sandy meadow area is chosen as the study area. The lake area information from 1986 to 2013 were extracted to analyze the variation law and spatial distribution characteristics using the multi temporal TM/ETM+ remote sensing images, based on remote sensing and GIS technology. The simulation and analysis of the lake area were performed using multivariate statistical analysis method combining with factors of precipitation, evaporation and the human activity effect time factor t. The results showed that: ①The numbers and area of lake in the study area have changed (increased or decreased) in the last 30 years, and the trends showed a strong positive correlation with the rainfall, while showed a negative correlation with evaporation, the influence of human activities to the small lake area was not significant, the lake area tended to shrink as time goes by, which was mainly attributed to the drying climate;②The lakes area in the year of t showed a strong correlation with the lake area of previous year, precipitation, and evaporation in the year of t, which can be simulated with the linear equations and nonlinear equations; ③the typical research area-the Wang Bahaga Lake, showed to be decreased during 1986-2013, but there were both atrophied and expanded in different directions: the I, II, V, VI region atrophied, while other regions expanded, the II, III, IV, VIII were dominant mutation direction, followed by the direction of VI, the other direction changed slowly. The region was marked as Ⅰ-Ⅷ by dividing the lake with every 45°, starting from north, clockwise. The results not only provided the technical support for the healthy maintain of Horqin sandy land ecosystem, but also could be a guidance for other similar lake areas.